Drug interactions
Elranatamab + Quinine
Severity: Moderate
Elranatamab and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab causes cytokine release syndrome that can temporarily suppress CYP enzyme activity, possibly raising quinine levels. Quinine has a narrow therapeutic window, so toxicity such as QT prolongation is possible.
What this interaction means in plain words
Elranatamab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity reduces quinine metabolism during cytokine release.
What to do
Monitor for quinine toxicity during step-up dosing and for about two weeks after, and during any cytokine release syndrome. Consider an ECG and a quinine dose adjustment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Quinine?
MediHelp rates the interaction as moderate. Elranatamab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab causes cytokine release syndrome that can temporarily suppress CYP enzyme activity, possibly raising quinine levels. Quinine has a narrow therapeutic window, so toxicity such as QT prolongation is possible.
How serious is the interaction between Elranatamab and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity during step-up dosing and for about two weeks after, and during any cytokine release syndrome. Consider an ECG and a quinine dose adjustment if needed.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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