Drug interactions
Eltrombopag + Etodolac
Severity: Minor
Eltrombopag and Etodolac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, which could in theory increase etodolac exposure, but clinical relevance has not been demonstrated. Both drugs may also affect bleeding or the liver.
What this interaction means in plain words
Eltrombopag and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Etodolac belongs to Musculoskeletal.
Why it happens
Theoretical UGT1A1 inhibition by eltrombopag reducing etodolac glucuronidation.
What to do
No routine adjustment is needed; monitor for NSAID adverse effects such as GI symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Etodolac?
MediHelp rates the interaction as minor. Eltrombopag and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, which could in theory increase etodolac exposure, but clinical relevance has not been demonstrated. Both drugs may also affect bleeding or the liver.
How serious is the interaction between Eltrombopag and Etodolac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for NSAID adverse effects such as GI symptoms.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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