Drug interactions
Eltrombopag + Imatinib
Severity: Minor
Eltrombopag and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may modestly increase eltrombopag exposure, possibly raising platelet response and hepatotoxicity risk. The clinical significance is uncertain.
What this interaction means in plain words
Eltrombopag and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Imatinib belongs to Oncology.
Why it happens
Possible inhibition of CYP2C9-mediated eltrombopag metabolism by imatinib.
What to do
Monitor platelet counts and liver tests; adjust eltrombopag dose per count.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Imatinib?
MediHelp rates the interaction as minor. Eltrombopag and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib may modestly increase eltrombopag exposure, possibly raising platelet response and hepatotoxicity risk. The clinical significance is uncertain.
How serious is the interaction between Eltrombopag and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and liver tests; adjust eltrombopag dose per count.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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