Drug interactions
Eltrombopag + Indomethacin
Severity: Minor
Eltrombopag and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro and could in theory raise indomethacin exposure. No clinically significant effect has been established.
What this interaction means in plain words
Eltrombopag and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible UGT1A1 inhibition by eltrombopag reducing indomethacin glucuronidation, clinical relevance unproven.
What to do
No routine adjustment is needed; be alert for NSAID adverse effects such as GI or renal toxicity. Note that NSAIDs may add bleeding risk in thrombocytopenic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Indomethacin?
MediHelp rates the interaction as minor. Eltrombopag and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro and could in theory raise indomethacin exposure. No clinically significant effect has been established.
How serious is the interaction between Eltrombopag and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be alert for NSAID adverse effects such as GI or renal toxicity. Note that NSAIDs may add bleeding risk in thrombocytopenic patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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