Drug interactions
Eltrombopag + Ketoprofen
Severity: Minor
Eltrombopag and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, which could raise ketoprofen exposure since it is cleared by glucuronidation. Clinical significance has not been established.
What this interaction means in plain words
Eltrombopag and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Ketoprofen belongs to Musculoskeletal.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of ketoprofen by eltrombopag, shown in vitro.
What to do
No routine adjustment is needed; monitor for NSAID adverse effects, and be aware that NSAIDs increase bleeding risk in thrombocytopenic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Ketoprofen?
MediHelp rates the interaction as minor. Eltrombopag and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, which could raise ketoprofen exposure since it is cleared by glucuronidation. Clinical significance has not been established.
How serious is the interaction between Eltrombopag and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for NSAID adverse effects, and be aware that NSAIDs increase bleeding risk in thrombocytopenic patients.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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