Drug interactions
Eltrombopag + Mexiletine
Severity: Minor
Eltrombopag and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag is not a major CYP1A2 substrate in a way that mexiletine inhibition would clearly affect, so a clinically relevant rise in exposure is not established. The interaction is theoretical.
What this interaction means in plain words
Eltrombopag and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Mexiletine belongs to Cardiovascular.
Why it happens
Theoretical CYP1A2 inhibition by mexiletine; not clearly established.
What to do
No dose change is needed; monitor platelet counts and liver tests as routinely recommended.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Mexiletine?
MediHelp rates the interaction as minor. Eltrombopag and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag is not a major CYP1A2 substrate in a way that mexiletine inhibition would clearly affect, so a clinically relevant rise in exposure is not established. The interaction is theoretical.
How serious is the interaction between Eltrombopag and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor platelet counts and liver tests as routinely recommended.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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