Drug interactions
Eltrombopag + Oxaprozin
Severity: Minor
Eltrombopag and Oxaprozin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, which could modestly raise exposure to drugs cleared by glucuronidation such as oxaprozin. The clinical significance is unclear.
What this interaction means in plain words
Eltrombopag and Oxaprozin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Oxaprozin belongs to Musculoskeletal.
Why it happens
Inhibition of UGT1A1 and UGT1A3 by eltrombopag may reduce oxaprozin glucuronidation.
What to do
No dose change is routinely needed. Monitor for NSAID adverse effects, especially bleeding, in thrombocytopenic patients, where NSAIDs are generally best avoided.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Oxaprozin?
MediHelp rates the interaction as minor. Eltrombopag and Oxaprozin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, which could modestly raise exposure to drugs cleared by glucuronidation such as oxaprozin. The clinical significance is unclear.
How serious is the interaction between Eltrombopag and Oxaprozin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for NSAID adverse effects, especially bleeding, in thrombocytopenic patients, where NSAIDs are generally best avoided.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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