Drug interactions
Eltrombopag + Oxymorphone
Severity: Minor
Eltrombopag and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT1A1 and some other UGT enzymes in vitro, and oxymorphone is cleared mainly via glucuronidation, so exposure could rise. The clinical significance has not been established.
What this interaction means in plain words
Eltrombopag and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Oxymorphone belongs to Musculoskeletal.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of oxymorphone.
What to do
No empirical dose change is needed; monitor for increased opioid effects such as sedation when eltrombopag is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Oxymorphone?
MediHelp rates the interaction as minor. Eltrombopag and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT1A1 and some other UGT enzymes in vitro, and oxymorphone is cleared mainly via glucuronidation, so exposure could rise. The clinical significance has not been established.
How serious is the interaction between Eltrombopag and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for increased opioid effects such as sedation when eltrombopag is started.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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