Drug interactions
Eltrombopag + Secobarbital
Severity: Moderate
Eltrombopag and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower eltrombopag exposure through enzyme induction, potentially blunting the platelet response. The effect is predicted from the mechanism and is of uncertain magnitude.
What this interaction means in plain words
Eltrombopag and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP1A2 and CYP2C9 (and possibly UGT) by secobarbital may increase eltrombopag clearance.
What to do
Monitor platelet counts regularly when starting or stopping secobarbital. Adjust the eltrombopag dose according to platelet response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Secobarbital?
MediHelp rates the interaction as moderate. Eltrombopag and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower eltrombopag exposure through enzyme induction, potentially blunting the platelet response. The effect is predicted from the mechanism and is of uncertain magnitude.
How serious is the interaction between Eltrombopag and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts regularly when starting or stopping secobarbital. Adjust the eltrombopag dose according to platelet response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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