Drug interactions
Eltrombopag + Simvastatin
Severity: Moderate
Eltrombopag and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1 and may increase systemic exposure to simvastatin acid, raising the risk of myopathy. Eltrombopag labeling advises considering a statin dose reduction when used together.
What this interaction means in plain words
Eltrombopag and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Why it happens
Eltrombopag inhibits the hepatic uptake transporter OATP1B1 (and BCRP), increasing statin exposure.
What to do
Consider lowering the simvastatin dose and monitor for muscle pain, weakness or dark urine, checking CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Simvastatin?
MediHelp rates the interaction as moderate. Eltrombopag and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits OATP1B1 and may increase systemic exposure to simvastatin acid, raising the risk of myopathy. Eltrombopag labeling advises considering a statin dose reduction when used together.
How serious is the interaction between Eltrombopag and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the simvastatin dose and monitor for muscle pain, weakness or dark urine, checking CK if symptoms occur.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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