Drug interactions
Eltrombopag + Sulindac
Severity: Minor
Eltrombopag and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, which could theoretically raise exposure to glucuronidated drugs such as sulindac metabolites. No clinically significant effect has been established.
What this interaction means in plain words
Eltrombopag and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Sulindac belongs to Musculoskeletal.
Why it happens
Theoretical UGT1A1 and UGT1A3 inhibition by eltrombopag; clinical relevance unproven.
What to do
No routine adjustment is needed; watch for increased NSAID adverse effects such as GI upset or edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Sulindac?
MediHelp rates the interaction as minor. Eltrombopag and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, which could theoretically raise exposure to glucuronidated drugs such as sulindac metabolites. No clinically significant effect has been established.
How serious is the interaction between Eltrombopag and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for increased NSAID adverse effects such as GI upset or edema.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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