Drug interactions
Eltrombopag + Sulphasalazine
Severity: Moderate
Eltrombopag and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits breast cancer resistance protein (BCRP) and can raise exposure to BCRP substrates such as sulfasalazine. Higher sulfasalazine levels may increase dose-related adverse effects, including nausea, headache and rash.
What this interaction means in plain words
Eltrombopag and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal BCRP efflux transport by eltrombopag, increasing sulfasalazine absorption.
What to do
Monitor for sulfasalazine adverse effects and consider a lower dose if intolerance develops. Review blood counts and liver tests as usual for sulfasalazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Sulphasalazine?
MediHelp rates the interaction as moderate. Eltrombopag and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits breast cancer resistance protein (BCRP) and can raise exposure to BCRP substrates such as sulfasalazine. Higher sulfasalazine levels may increase dose-related adverse effects, including nausea, headache and rash.
How serious is the interaction between Eltrombopag and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects and consider a lower dose if intolerance develops. Review blood counts and liver tests as usual for sulfasalazine.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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