Drug interactions
Eltrombopag + Zinc
Severity: Moderate
Eltrombopag and Zinc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag chelates polyvalent cations such as zinc, calcium, iron and aluminium in the gut. Co-administration reduces eltrombopag absorption and may lower the platelet response.
What this interaction means in plain words
Eltrombopag and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Zinc belongs to Gastrointestinal Tract.
Why it happens
Chelation of eltrombopag by zinc in the gastrointestinal tract reduces its absorption.
What to do
Give eltrombopag at least 2 hours before or 4 hours after zinc-containing products. Monitor platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eltrombopag and Zinc, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Zinc
- Alendronate + Zinc Moderate
- Baloxavir marboxil + Zinc Moderate
- Cefalexin + Zinc Moderate
- Ciprofloxacin + Zinc Moderate
- Delafloxacin + Zinc Moderate
- Dolutegravir + Zinc Moderate
Frequently asked questions
Can I take Eltrombopag with Zinc?
MediHelp rates the interaction as moderate. Eltrombopag and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag chelates polyvalent cations such as zinc, calcium, iron and aluminium in the gut. Co-administration reduces eltrombopag absorption and may lower the platelet response.
How serious is the interaction between Eltrombopag and Zinc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give eltrombopag at least 2 hours before or 4 hours after zinc-containing products. Monitor platelet counts.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
