Drug interactions
Eluxadoline + Erythromycin
Severity: Moderate
Eluxadoline and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase eluxadoline exposure, probably by inhibiting hepatic uptake transport. Higher eluxadoline levels raise the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eluxadoline and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of eluxadoline increases its systemic exposure.
What to do
Reduce eluxadoline to 75 mg twice daily during co-administration and monitor for constipation, abdominal pain and pancreatitis symptoms. Consider an alternative antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Erythromycin?
MediHelp rates the interaction as moderate. Eluxadoline and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase eluxadoline exposure, probably by inhibiting hepatic uptake transport. Higher eluxadoline levels raise the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eluxadoline and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily during co-administration and monitor for constipation, abdominal pain and pancreatitis symptoms. Consider an alternative antibiotic if feasible.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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