Drug interactions
Eluxadoline + Flurbiprofen
Severity: Minor
Eluxadoline and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen is a CYP2C9 substrate and not a strong inhibitor, so a meaningful effect on eluxadoline exposure is not expected. Any interaction is speculative.
What this interaction means in plain words
Eluxadoline and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Not established; theoretical competition at CYP2C9 only.
What to do
No action beyond awareness is needed; monitor for eluxadoline adverse effects such as constipation or abdominal pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Flurbiprofen?
MediHelp rates the interaction as minor. Eluxadoline and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flurbiprofen is a CYP2C9 substrate and not a strong inhibitor, so a meaningful effect on eluxadoline exposure is not expected. Any interaction is speculative.
How serious is the interaction between Eluxadoline and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness is needed; monitor for eluxadoline adverse effects such as constipation or abdominal pain.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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