Drug interactions
Eluxadoline + Glyburide-metformin
Severity: Moderate
Eluxadoline and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an OATP1B1 substrate, and glyburide may inhibit OATP1B1 and raise eluxadoline concentrations. Higher eluxadoline exposure may increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eluxadoline and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Glyburide-metformin belongs to Endocrine.
Why it happens
Glyburide may inhibit OATP1B1-mediated hepatic uptake of eluxadoline, increasing its systemic exposure.
What to do
Consider reducing eluxadoline to 75 mg twice daily if used with glyburide. Monitor for gastrointestinal adverse effects and pancreatitis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Glyburide-metformin?
MediHelp rates the interaction as moderate. Eluxadoline and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is an OATP1B1 substrate, and glyburide may inhibit OATP1B1 and raise eluxadoline concentrations. Higher eluxadoline exposure may increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eluxadoline and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing eluxadoline to 75 mg twice daily if used with glyburide. Monitor for gastrointestinal adverse effects and pancreatitis symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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