Drug interactions
Eluxadoline + Hydrochlorothiazide-valsartan
Severity: Moderate
Eluxadoline and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an OATP1B1 substrate, and inhibitors of this transporter increase its exposure. Valsartan is reported to inhibit OATP1B1, so eluxadoline levels may rise, with greater risk of adverse effects such as constipation, nausea, and pancreatitis.
What this interaction means in plain words
Eluxadoline and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of eluxadoline reduces its clearance.
What to do
Use the reduced eluxadoline dose of 75 mg twice daily recommended with OATP1B1 inhibitors. Monitor for abdominal pain and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Eluxadoline and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is an OATP1B1 substrate, and inhibitors of this transporter increase its exposure. Valsartan is reported to inhibit OATP1B1, so eluxadoline levels may rise, with greater risk of adverse effects such as constipation, nausea, and pancreatitis.
How serious is the interaction between Eluxadoline and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced eluxadoline dose of 75 mg twice daily recommended with OATP1B1 inhibitors. Monitor for abdominal pain and constipation.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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