Drug interactions
Eluxadoline + Irinotecan
Severity: Moderate
Eluxadoline and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline may inhibit BCRP and raise exposure to irinotecan and SN-38. Eluxadoline also slows bowel motility and may mask or complicate irinotecan-induced diarrhea.
What this interaction means in plain words
Eluxadoline and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Irinotecan belongs to Oncology.
Why it happens
Eluxadoline inhibits BCRP and OATP transport, potentially increasing irinotecan exposure.
What to do
Monitor for diarrhea and neutropenia. Reduce the irinotecan dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Irinotecan?
MediHelp rates the interaction as moderate. Eluxadoline and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline may inhibit BCRP and raise exposure to irinotecan and SN-38. Eluxadoline also slows bowel motility and may mask or complicate irinotecan-induced diarrhea.
How serious is the interaction between Eluxadoline and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia. Reduce the irinotecan dose if toxicity develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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