Drug interactions
Eluxadoline + Ketoconazole
Severity: Moderate
Eluxadoline and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise eluxadoline exposure, increasing risks such as pancreatitis, constipation and CNS effects. The effect is probably modest but is of concern given eluxadoline's safety profile.
What this interaction means in plain words
Eluxadoline and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole may inhibit transporters, including OATP1B1, involved in eluxadoline disposition; CYP3A4 plays only a minor role.
What to do
Monitor for adverse effects and consider using the reduced 75 mg twice daily eluxadoline dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Ketoconazole?
MediHelp rates the interaction as moderate. Eluxadoline and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may raise eluxadoline exposure, increasing risks such as pancreatitis, constipation and CNS effects. The effect is probably modest but is of concern given eluxadoline's safety profile.
How serious is the interaction between Eluxadoline and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and consider using the reduced 75 mg twice daily eluxadoline dose.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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