Drug interactions
Eluxadoline + Methadone
Severity: Moderate
Eluxadoline and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as methadone slow gut transit and cause constipation, and eluxadoline carries a risk of serious constipation-related complications including pancreatitis and obstruction. The combination raises this risk and eluxadoline is meant to be avoided with drugs that cause severe constipation.
What this interaction means in plain words
Eluxadoline and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Methadone belongs to Musculoskeletal.
Why it happens
Additive effects on opioid receptors in the gut reducing motility.
What to do
Avoid concomitant use where possible, and if started, stop eluxadoline when severe constipation develops. Monitor bowel function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Methadone?
MediHelp rates the interaction as moderate. Eluxadoline and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as methadone slow gut transit and cause constipation, and eluxadoline carries a risk of serious constipation-related complications including pancreatitis and obstruction. The combination raises this risk and eluxadoline is meant to be avoided with drugs that cause severe constipation.
How serious is the interaction between Eluxadoline and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible, and if started, stop eluxadoline when severe constipation develops. Monitor bowel function closely.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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