Drug interactions
Eluxadoline + Paroxetine
Severity: Moderate
Eluxadoline and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine may increase eluxadoline exposure because it strongly inhibits CYP2D6, although the metabolism of eluxadoline is incompletely characterized. Higher levels could increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eluxadoline and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Paroxetine belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP2D6-mediated eluxadoline metabolism; the contribution is not well established.
What to do
Monitor for gastrointestinal adverse effects such as constipation and abdominal pain. Stop eluxadoline if severe constipation or pancreatitis symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Paroxetine?
MediHelp rates the interaction as moderate. Eluxadoline and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine may increase eluxadoline exposure because it strongly inhibits CYP2D6, although the metabolism of eluxadoline is incompletely characterized. Higher levels could increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eluxadoline and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects such as constipation and abdominal pain. Stop eluxadoline if severe constipation or pancreatitis symptoms develop.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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