Drug interactions
Eluxadoline + Pazopanib
Severity: Moderate
Eluxadoline and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1, a transporter that moves eluxadoline into the liver. Eluxadoline exposure may therefore rise, increasing the risk of its adverse effects such as constipation, nausea and pancreatitis.
What this interaction means in plain words
Eluxadoline and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of eluxadoline.
What to do
Reduce eluxadoline to 75 mg twice daily while pazopanib is used. Monitor for abdominal pain, constipation and pancreatitis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Pazopanib?
MediHelp rates the interaction as moderate. Eluxadoline and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits OATP1B1, a transporter that moves eluxadoline into the liver. Eluxadoline exposure may therefore rise, increasing the risk of its adverse effects such as constipation, nausea and pancreatitis.
How serious is the interaction between Eluxadoline and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily while pazopanib is used. Monitor for abdominal pain, constipation and pancreatitis symptoms.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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