Drug interactions
Eluxadoline + Quinine
Severity: Minor
Eluxadoline and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline may modestly inhibit CYP3A4 and raise levels of sensitive substrates such as quinine. The clinical significance is likely small, but quinine has a narrow therapeutic index.
What this interaction means in plain words
Eluxadoline and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Quinine belongs to Anti Parasitic.
Why it happens
Weak inhibition of CYP3A4 metabolism by eluxadoline may slightly increase quinine exposure.
What to do
Monitor for quinine adverse effects such as tinnitus and dizziness. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Quinine?
MediHelp rates the interaction as minor. Eluxadoline and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline may modestly inhibit CYP3A4 and raise levels of sensitive substrates such as quinine. The clinical significance is likely small, but quinine has a narrow therapeutic index.
How serious is the interaction between Eluxadoline and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine adverse effects such as tinnitus and dizziness. No routine dose change is needed.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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