Drug interactions
Eluxadoline + Sacubitril-valsartan
Severity: Moderate
Eluxadoline and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril/valsartan components may inhibit OATP1B1 and raise eluxadoline exposure, increasing risks such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eluxadoline and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of hepatic OATP1B1 uptake reduces eluxadoline clearance.
What to do
Consider reducing eluxadoline to 75 mg twice daily and monitor for abdominal pain, constipation and pancreatitis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Eluxadoline and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sacubitril/valsartan components may inhibit OATP1B1 and raise eluxadoline exposure, increasing risks such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eluxadoline and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing eluxadoline to 75 mg twice daily and monitor for abdominal pain, constipation and pancreatitis symptoms.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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