Drug interactions
Eluxadoline + Sulphasalazine
Severity: Moderate
Eluxadoline and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits BCRP and can increase exposure to BCRP substrates such as sulfasalazine. This may increase sulfasalazine related adverse effects.
What this interaction means in plain words
Eluxadoline and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Eluxadoline inhibits intestinal BCRP efflux, increasing sulfasalazine absorption.
What to do
Monitor for sulfasalazine toxicity and consider a lower sulfasalazine dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Sulphasalazine?
MediHelp rates the interaction as moderate. Eluxadoline and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline inhibits BCRP and can increase exposure to BCRP substrates such as sulfasalazine. This may increase sulfasalazine related adverse effects.
How serious is the interaction between Eluxadoline and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine toxicity and consider a lower sulfasalazine dose if adverse effects arise.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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