Drug interactions
Eluxadoline + Valsartan
Severity: Minor
Eluxadoline and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an OATP1B1 substrate, and OATP1B1 inhibitors raise its exposure. Valsartan is a weak OATP1B1 substrate and not a well-established inhibitor, so a meaningful interaction is uncertain.
What this interaction means in plain words
Eluxadoline and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Valsartan belongs to Cardiovascular.
Why it happens
Possible competition at OATP1B1 uptake; not well established.
What to do
No dose change required; monitor for eluxadoline adverse effects such as constipation and abdominal pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Valsartan?
MediHelp rates the interaction as minor. Eluxadoline and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline is an OATP1B1 substrate, and OATP1B1 inhibitors raise its exposure. Valsartan is a weak OATP1B1 substrate and not a well-established inhibitor, so a meaningful interaction is uncertain.
How serious is the interaction between Eluxadoline and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change required; monitor for eluxadoline adverse effects such as constipation and abdominal pain.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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