Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Glipizide
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may induce CYP2C9 modestly, while cobicistat inhibits some enzymes, so glipizide exposure and effect could change in either direction. The net effect is uncertain.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CYP2C9 induction by elvitegravir and enzyme inhibition by cobicistat may alter glipizide metabolism.
What to do
Monitor blood glucose after starting or stopping the regimen and adjust glipizide dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Glipizide?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir may induce CYP2C9 modestly, while cobicistat inhibits some enzymes, so glipizide exposure and effect could change in either direction. The net effect is uncertain.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping the regimen and adjust glipizide dose if control changes.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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