Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ixazomib
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ixazomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component strongly inhibits CYP3A4, but strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. No clinically important interaction is expected.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cobicistat inhibits CYP3A4, which contributes little to ixazomib clearance.
What to do
No dose adjustment is needed; monitor routinely for ixazomib toxicity and for renal function with tenofovir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ixazomib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ixazomib?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The cobicistat component strongly inhibits CYP3A4, but strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. No clinically important interaction is expected.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ixazomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor routinely for ixazomib toxicity and for renal function with tenofovir.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
