Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lacosamide
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor, but lacosamide relies on CYP3A4 only minimally. Any increase in exposure is expected to be small, though cobicistat can also affect PR interval at higher exposures.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cobicistat inhibits CYP3A4, slightly reducing lacosamide metabolism.
What to do
No routine dose adjustment is needed. Monitor for dizziness and conduction symptoms, particularly in renal or hepatic impairment or with other PR-prolonging drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Lacosamide?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is a strong CYP3A4 inhibitor, but lacosamide relies on CYP3A4 only minimally. Any increase in exposure is expected to be small, though cobicistat can also affect PR interval at higher exposures.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor for dizziness and conduction symptoms, particularly in renal or hepatic impairment or with other PR-prolonging drugs.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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