Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Methamphetamine
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP2D6 and may raise methamphetamine concentrations. This can increase stimulant effects such as hypertension, tachycardia and agitation.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP2D6-mediated methamphetamine metabolism.
What to do
Monitor heart rate, blood pressure and stimulant toxicity when starting the combination. Consider reducing the methamphetamine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Methamphetamine?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP2D6 and may raise methamphetamine concentrations. This can increase stimulant effects such as hypertension, tachycardia and agitation.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and stimulant toxicity when starting the combination. Consider reducing the methamphetamine dose if needed.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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