Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Modafinil
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat strongly inhibits CYP3A4, which contributes to modafinil clearance, so modafinil levels may rise. This could increase adverse effects such as anxiety, insomnia, headache and blood pressure elevation.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4-mediated metabolism of modafinil.
What to do
Monitor for stimulant adverse effects and blood pressure, and reduce the modafinil dose if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Modafinil?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat strongly inhibits CYP3A4, which contributes to modafinil clearance, so modafinil levels may rise. This could increase adverse effects such as anxiety, insomnia, headache and blood pressure elevation.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for stimulant adverse effects and blood pressure, and reduce the modafinil dose if tolerability problems arise.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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