Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component strongly inhibits CYP3A4 and can increase systemic mometasone exposure. This raises the risk of Cushing's syndrome and adrenal suppression, especially with prolonged use.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing mometasone clearance.
What to do
Consider beclomethasone for long-term therapy. If coadministered, use the lowest effective dose and monitor for corticosteroid excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Fosamprenavir + Mometasone Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Mometasone?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cobicistat component strongly inhibits CYP3A4 and can increase systemic mometasone exposure. This raises the risk of Cushing's syndrome and adrenal suppression, especially with prolonged use.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider beclomethasone for long-term therapy. If coadministered, use the lowest effective dose and monitor for corticosteroid excess.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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