Drug interactions
Fosamprenavir + Mometasone
Severity: Moderate
Fosamprenavir and Mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, which inhibits CYP3A4 and may raise systemic mometasone exposure. Prolonged use may lead to Cushing's syndrome and adrenal suppression.
What this interaction means in plain words
Fosamprenavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4 metabolism of mometasone, especially when boosted with ritonavir.
What to do
Monitor for corticosteroid excess and adrenal suppression. Consider beclomethasone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Frequently asked questions
Can I take Fosamprenavir with Mometasone?
MediHelp rates the interaction as moderate. Fosamprenavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir is converted to amprenavir, which inhibits CYP3A4 and may raise systemic mometasone exposure. Prolonged use may lead to Cushing's syndrome and adrenal suppression.
How serious is the interaction between Fosamprenavir and Mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and adrenal suppression. Consider beclomethasone for long-term therapy.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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