Drug interactions
Mometasone + Ritonavir
Severity: Major
Mometasone and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and can substantially increase systemic mometasone exposure. Cushing's syndrome and adrenal suppression have been reported with ritonavir and CYP3A4-metabolized inhaled or intranasal corticosteroids.
What this interaction means in plain words
Mometasone and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mometasone belongs to Respiratory; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir strongly inhibits CYP3A4, reducing mometasone clearance.
What to do
Prefer beclomethasone or another less CYP3A4-dependent corticosteroid for long-term use with ritonavir. If coadministered, use the lowest effective dose and monitor for Cushing's features and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mometasone
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
- Fosamprenavir + Mometasone Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Mometasone with Ritonavir?
MediHelp rates the interaction as major. Mometasone and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir strongly inhibits CYP3A4 and can substantially increase systemic mometasone exposure. Cushing's syndrome and adrenal suppression have been reported with ritonavir and CYP3A4-metabolized inhaled or intranasal corticosteroids.
How serious is the interaction between Mometasone and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer beclomethasone or another less CYP3A4-dependent corticosteroid for long-term use with ritonavir. If coadministered, use the lowest effective dose and monitor for Cushing's features and adrenal suppression.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Mometasone page.
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