Drug interactions
Atazanavir + Mometasone
Severity: Moderate
Atazanavir and Mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can increase systemic exposure to mometasone. This may lead to Cushing's syndrome and adrenal suppression with prolonged use.
What this interaction means in plain words
Atazanavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Mometasone belongs to Respiratory.
Why it happens
Atazanavir inhibits CYP3A4-mediated metabolism of mometasone, increasing systemic exposure.
What to do
Monitor for corticosteroid excess and adrenal suppression with long-term use. Consider beclomethasone as an alternative if prolonged coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Mometasone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
- Fosamprenavir + Mometasone Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Mometasone?
MediHelp rates the interaction as moderate. Atazanavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can increase systemic exposure to mometasone. This may lead to Cushing's syndrome and adrenal suppression with prolonged use.
How serious is the interaction between Atazanavir and Mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and adrenal suppression with long-term use. Consider beclomethasone as an alternative if prolonged coadministration is needed.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Clarithromycin, Cobicistat. The full list is on the Mometasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
