Drug interactions
Cobicistat + Mometasone
Severity: Moderate
Cobicistat and Mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and can raise systemic exposure to mometasone. This increases the risk of Cushing's syndrome and adrenal suppression, mainly with long-term use.
What this interaction means in plain words
Cobicistat and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Mometasone belongs to Respiratory.
Why it happens
Cobicistat inhibits CYP3A4, reducing first-pass and systemic clearance of mometasone.
What to do
Consider beclomethasone for long-term therapy. If coadministered, use the lowest effective mometasone dose and monitor for corticosteroid excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
- Fosamprenavir + Mometasone Moderate
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Mometasone?
MediHelp rates the interaction as moderate. Cobicistat and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and can raise systemic exposure to mometasone. This increases the risk of Cushing's syndrome and adrenal suppression, mainly with long-term use.
How serious is the interaction between Cobicistat and Mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider beclomethasone for long-term therapy. If coadministered, use the lowest effective mometasone dose and monitor for corticosteroid excess.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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