Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Nevirapine
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This single-tablet regimen is complete and is not designed to be used with other antiretrovirals. Nevirapine may lower elvitegravir and cobicistat exposure, while cobicistat may raise nevirapine levels, creating a risk of virologic failure and toxicity.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4 reducing elvitegravir and cobicistat exposure, while cobicistat inhibits CYP3A4 and may raise nevirapine levels.
What to do
Do not coadminister; use a single complete regimen or a different combination without duplicate therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Nevirapine?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This single-tablet regimen is complete and is not designed to be used with other antiretrovirals. Nevirapine may lower elvitegravir and cobicistat exposure, while cobicistat may raise nevirapine levels, creating a risk of virologic failure and toxicity.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a single complete regimen or a different combination without duplicate therapy.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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