Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ondansetron
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and may modestly raise ondansetron exposure. Ondansetron prolongs the QT interval in a dose-related manner, so higher levels increase arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4, one of several pathways of ondansetron metabolism.
What to do
Use the lowest effective ondansetron dose and consider ECG monitoring in patients with QT risk factors. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ondansetron?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and may modestly raise ondansetron exposure. Ondansetron prolongs the QT interval in a dose-related manner, so higher levels increase arrhythmia risk, especially with other risk factors.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ondansetron dose and consider ECG monitoring in patients with QT risk factors. Correct electrolyte abnormalities.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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