Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Risperidone
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component inhibits CYP2D6 and CYP3A4 and can raise risperidone and active metabolite concentrations. This may increase sedation, extrapyramidal symptoms and hypotension.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP2D6 and CYP3A4, reducing risperidone metabolism.
What to do
Consider reducing the risperidone dose when starting the combination and monitor for extrapyramidal symptoms and sedation. Adjust the dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Risperidone?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cobicistat component inhibits CYP2D6 and CYP3A4 and can raise risperidone and active metabolite concentrations. This may increase sedation, extrapyramidal symptoms and hypotension.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the risperidone dose when starting the combination and monitor for extrapyramidal symptoms and sedation. Adjust the dose according to clinical response.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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