Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ropivacaine
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ropivacaine is metabolized partly by CYP3A4 and CYP1A2, and cobicistat inhibits CYP3A4. Plasma levels may rise modestly, increasing the potential for local anesthetic toxicity with prolonged infusions.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4-mediated ropivacaine metabolism.
What to do
Avoid prolonged ropivacaine infusions where possible, or reduce the dose and monitor for neurologic and cardiac signs of local anesthetic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ropivacaine?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ropivacaine is metabolized partly by CYP3A4 and CYP1A2, and cobicistat inhibits CYP3A4. Plasma levels may rise modestly, increasing the potential for local anesthetic toxicity with prolonged infusions.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged ropivacaine infusions where possible, or reduce the dose and monitor for neurologic and cardiac signs of local anesthetic toxicity.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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