Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Temsirolimus
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and can raise concentrations of temsirolimus and its active metabolite sirolimus. This may increase mTOR-related toxicities such as mucositis, myelosuppression, hyperglycemia, hyperlipidemia and pneumonitis.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4 (and P-gp), reducing metabolism of temsirolimus and sirolimus.
What to do
Avoid the combination if possible and consider an alternative antiretroviral regimen. If unavoidable, reduce the temsirolimus dose and monitor blood counts, glucose, lipids and toxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Temsirolimus?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 inhibitor and can raise concentrations of temsirolimus and its active metabolite sirolimus. This may increase mTOR-related toxicities such as mucositis, myelosuppression, hyperglycemia, hyperlipidemia and pneumonitis.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider an alternative antiretroviral regimen. If unavoidable, reduce the temsirolimus dose and monitor blood counts, glucose, lipids and toxicity closely.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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