Drug interactions
Empagliflozin-linagliptin + Hydrochlorothiazide
Severity: Moderate
Empagliflozin-linagliptin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin and hydrochlorothiazide both promote fluid and sodium loss, which can lead to volume depletion, hypotension and electrolyte abnormalities.
What this interaction means in plain words
Empagliflozin-linagliptin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects.
What to do
Monitor blood pressure, volume status, electrolytes and renal function after starting. Reduce the thiazide dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Empagliflozin-linagliptin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin and hydrochlorothiazide both promote fluid and sodium loss, which can lead to volume depletion, hypotension and electrolyte abnormalities.
How serious is the interaction between Empagliflozin-linagliptin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, electrolytes and renal function after starting. Reduce the thiazide dose if volume depletion occurs.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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