Drug interactions
Empagliflozin-linagliptin + Lopinavir
Severity: Moderate
Empagliflozin-linagliptin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir (boosted with ritonavir) can raise linagliptin exposure through CYP3A4 and P-gp inhibition, though linagliptin has a wide safety margin. Protease inhibitors can also worsen insulin resistance and glycemic control, which may reduce the benefit of the antidiabetic combination.
What this interaction means in plain words
Empagliflozin-linagliptin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by the lopinavir/ritonavir combination, plus protease inhibitor-associated insulin resistance and hyperglycemia.
What to do
Monitor blood glucose and HbA1c after starting or stopping lopinavir and adjust antidiabetic therapy as needed. No routine linagliptin dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Empagliflozin-linagliptin with Lopinavir?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir (boosted with ritonavir) can raise linagliptin exposure through CYP3A4 and P-gp inhibition, though linagliptin has a wide safety margin. Protease inhibitors can also worsen insulin resistance and glycemic control, which may reduce the benefit of the antidiabetic combination.
How serious is the interaction between Empagliflozin-linagliptin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping lopinavir and adjust antidiabetic therapy as needed. No routine linagliptin dose change is needed.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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