Drug interactions
Empagliflozin-linagliptin + Nevirapine
Severity: Moderate
Empagliflozin-linagliptin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may reduce linagliptin exposure, which could weaken glucose control. Linagliptin labeling advises using an alternative to strong inducers.
What this interaction means in plain words
Empagliflozin-linagliptin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 (and possibly P-glycoprotein) increases linagliptin clearance.
What to do
Monitor blood glucose and HbA1c, and consider an alternative antidiabetic agent if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Nevirapine?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may reduce linagliptin exposure, which could weaken glucose control. Linagliptin labeling advises using an alternative to strong inducers.
How serious is the interaction between Empagliflozin-linagliptin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c, and consider an alternative antidiabetic agent if control worsens.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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