Drug interactions
Empagliflozin-metformin + Ethacrynic acid
Severity: Moderate
Empagliflozin-metformin and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin combined with a loop diuretic increases urine output and can cause volume depletion, hypotension and electrolyte disturbance. Acute kidney injury is a concern in vulnerable patients.
What this interaction means in plain words
Empagliflozin-metformin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects.
What to do
Monitor hydration, blood pressure, electrolytes and renal function; reduce the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-metformin and Ethacrynic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Empagliflozin-metformin with Ethacrynic acid?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin combined with a loop diuretic increases urine output and can cause volume depletion, hypotension and electrolyte disturbance. Acute kidney injury is a concern in vulnerable patients.
How serious is the interaction between Empagliflozin-metformin and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hydration, blood pressure, electrolytes and renal function; reduce the diuretic dose if volume depletion occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
