Drug interactions
Empagliflozin-metformin + Fluphenazine
Severity: Moderate
Empagliflozin-metformin and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can cause hyperglycemia and impaired glucose tolerance, which may weaken glycemic control. Fluphenazine has a lower metabolic liability than many other antipsychotics, but changes are possible.
What this interaction means in plain words
Empagliflozin-metformin and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Fluphenazine belongs to Central Nervous System.
Why it happens
Dopamine and other receptor antagonism may reduce insulin secretion and sensitivity, opposing the antidiabetic effect.
What to do
Monitor blood glucose and HbA1c after starting fluphenazine, and adjust antidiabetic therapy as needed. Watch for hypoglycemia if fluphenazine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-metformin and Fluphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Empagliflozin-metformin with Fluphenazine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics can cause hyperglycemia and impaired glucose tolerance, which may weaken glycemic control. Fluphenazine has a lower metabolic liability than many other antipsychotics, but changes are possible.
How serious is the interaction between Empagliflozin-metformin and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting fluphenazine, and adjust antidiabetic therapy as needed. Watch for hypoglycemia if fluphenazine is withdrawn.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
