Drug interactions
Empagliflozin-metformin + Fluvoxamine
Severity: Minor
Empagliflozin-metformin and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may enhance glucose-lowering and has been associated with hypoglycemia in patients on antidiabetic drugs. It is also a CYP inhibitor, though metformin is not CYP metabolized, so the effect is mainly pharmacodynamic.
What this interaction means in plain words
Empagliflozin-metformin and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Fluvoxamine belongs to Central Nervous System.
Why it happens
SSRIs may improve insulin sensitivity, giving an additive glucose-lowering effect; the mechanism is not fully established.
What to do
Monitor blood glucose when fluvoxamine is started or stopped. Adjust antidiabetic dosing only if hypoglycemia or hyperglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Fluvoxamine?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine may enhance glucose-lowering and has been associated with hypoglycemia in patients on antidiabetic drugs. It is also a CYP inhibitor, though metformin is not CYP metabolized, so the effect is mainly pharmacodynamic.
How serious is the interaction between Empagliflozin-metformin and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluvoxamine is started or stopped. Adjust antidiabetic dosing only if hypoglycemia or hyperglycemia occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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