Drug interactions
Empagliflozin-metformin + Furosemide
Severity: Moderate
Empagliflozin-metformin and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin causes osmotic diuresis and natriuresis, which adds to the diuretic effect of furosemide. This can lead to volume depletion, hypotension and acute kidney injury, which also raises the risk of metformin accumulation.
What this interaction means in plain words
Empagliflozin-metformin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Furosemide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects produce intravascular volume depletion.
What to do
Assess volume status and renal function before and after starting; consider reducing the loop diuretic dose in at-risk patients. Monitor blood pressure, electrolytes and creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Empagliflozin-metformin with Furosemide?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin causes osmotic diuresis and natriuresis, which adds to the diuretic effect of furosemide. This can lead to volume depletion, hypotension and acute kidney injury, which also raises the risk of metformin accumulation.
How serious is the interaction between Empagliflozin-metformin and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting; consider reducing the loop diuretic dose in at-risk patients. Monitor blood pressure, electrolytes and creatinine.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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