Drug interactions
Empagliflozin-metformin + Iloperidone
Severity: Moderate
Empagliflozin-metformin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can cause weight gain, hyperglycemia and insulin resistance. This may reduce the effectiveness of the antidiabetic combination.
What this interaction means in plain words
Empagliflozin-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related metabolic effects, including insulin resistance, oppose glucose-lowering therapy.
What to do
Monitor fasting glucose, HbA1c and weight at baseline and periodically. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Empagliflozin-metformin with Iloperidone?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can cause weight gain, hyperglycemia and insulin resistance. This may reduce the effectiveness of the antidiabetic combination.
How serious is the interaction between Empagliflozin-metformin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose, HbA1c and weight at baseline and periodically. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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