Drug interactions
Empagliflozin-metformin + Memantine
Severity: Minor
Empagliflozin-metformin and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is a cationic drug eliminated partly by renal tubular secretion and may compete with metformin for clearance. This could slightly raise exposure to either drug, but the effect is generally small.
What this interaction means in plain words
Empagliflozin-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Memantine belongs to Central Nervous System.
Why it happens
Competition for renal tubular cationic transport (OCT2/MATE) reduces clearance of metformin.
What to do
No routine adjustment is needed. Monitor renal function and metformin tolerability in patients with kidney impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Empagliflozin-metformin with Memantine?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is a cationic drug eliminated partly by renal tubular secretion and may compete with metformin for clearance. This could slightly raise exposure to either drug, but the effect is generally small.
How serious is the interaction between Empagliflozin-metformin and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and metformin tolerability in patients with kidney impairment.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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